Acute hepatocellular injury (Hepatitis)
Hepatocellular injury is defined as an R ratio greater than 5, cholestatic injury has an R ratio less than 2, and “mixed” cholestatic-hepatocellular injury has an R ratio between 2 and 5. Acute hepatitis is a term used to describe a wide variety of conditions characterized by acute inflammation of the hepatic parenchyma or injury to hepatocytes resulting in elevated liver function indices. In general, hepatitis is classified as acute or chronic based on the duration of the inflammation and insult to the hepatic parenchyma. If the period of inflammation or hepatocellular injury lasts for less than six months, characterized by normalization of the liver function tests, it is called acute hepatitis. In contrast, if the inflammation or hepatocellular injury persists beyond six months, it is termed chronic hepatitis.
| Known Toxin and Potential effects | |||
|---|---|---|---|
| Strong | Good | Limited | |
| Known Toxin and Potential effects | Carbon tetrachloride, Tetrachloroethanes, Trichloroethylene (TCE), Trinitrotoluene (TNT) | Polychlorinated Byphenyls (PCBs), Trichloroethane | Toluene (BTEX compounds), Xylene, Antimony |